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- Title
Alcoholism, Nonprescription Drugs and Hepatotoxicity.
- Authors
Johnson, Michael W.; Friedman, Paul A.; Mitch, William E.
- Abstract
An alcoholic patient developed severe hepatitis and renal failure after ingesting the contents of a 300 ml. bottle of Nyquil® for its ethanol content. This illness was presumably related to the 6 gm. of acetaminophen contained in this nonprescription preparation. Although hepatic damage with or without renal failure is usually described after a massive overdose of acetaminophen, the changes in drug metabolism induced by chronic ethanol consumption may increase the risk for acetaminophen toxicity. The large number of nonprescription acetaminophen ethanol preparations available should be considered in evaluating an alcoholic patient seen with acute hepatic and renal dysfunction.
- Publication
American Journal of Gastroenterology (Springer Nature), 1981, Vol 76, Issue 6, p530
- ISSN
0002-9270
- Publication type
Academic Journal