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- Title
Immunogenetic Aspects of Primary Sclerosing Cholangitis: Implications for Therapeutic Strategies.
- Authors
Van Millgen de Wit, A. W. Marc; Van Deventer, Sunder J. H.; Tytgat, Guido N. J.
- Abstract
Primary sclenrosing cholangitis (PSC) is a chronic cholestalic liver disease characterized by fibro-obliteralive inflammation of the intra-and extrahepatic bile ducts; in 70% of cases, it is associated with inflammatory bowel disease. The disease usually runs a progressive course, ultimately leading to biliary cirrhosis, hepatic failure, and sometimes cbolangiocarcinoma, with a median survival of 12 yr after diagnosis. As yet, the etiology of primary sclerosing cholangitis remains unknown, although several recent studies have implicated immunogenetic factors as important pathogenic mechanisms. Besides liver transplantation for patients with end-stage cirrhotic liver disease and endoscopic therapy for patients with dominant extrahepatic bile duct strictures, recent studies have also shown promising results of drug therapy with ursodeoxycholic acid in the treatment of PSC. The purpose of this article is to summarise our current knowledge of the immunogenetic factors in the pathogenesis of PSC and to present support for drug therapy with ursodeoxycholic acid in the treatment of PSC. The genetic and immunological factors in the pathogenesis of PSC are outlined first, followed by a rationale of drug therapy with ursodeoxycholic acid in the treatment of PSC.
- Publication
American Journal of Gastroenterology (Springer Nature), 1995, Vol 90, Issue 6, p893
- ISSN
0002-9270
- Publication type
Academic Journal