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- Title
THE EFFECTS ON BLOOD SUGAR AND KETONE BODIES OF BUTYRATE, ACETATE AND Β-OH BUTYRATE INFUSED INTO SHEEP.
- Authors
Kronfeld, D. S.
- Abstract
Solutions of butyrate, acetate and β-0H butyrate were given to sheep by intravenous infusion. Samples of carotid and jugular blood were drawn simultaneously before and after infusion. Reducing sugar, volatile fatty acids and ketone bodies were estimated in the blood. After butyrate infusion, rises in sugar were found when the initial sugar level was low, and falls in sugar occurred when the initial level was high. The regression of change in sugar concentration upon initial sugar concentration was highly significant. Large rises in sugar were associated with small increases or negligible change of ketone concentration, whereas small rises or falls in glucose were associated with larger increases of ketones. After acetate infusion, both ketones and sugar levels increased although the changes were less marked than after butyrate. After β-OH butyrate infusion, there were marked increases in blood sugar, and utilisation of volatile fatty acid decreased. Many carotid-jugular differences of reducing sugar and ketone bodies were negative after the infusion of butyrate, acetate or β-OH butyrate. The experiments suggest that butyrate, β-OH butyrate and acetate may be converted to glucose in sheep, that ketones may be intermediaries in the con-version of the volatile fatty acids to glucose, and that the tissues of the head may participate in ketogenesis and gluconeogenesis.
- Publication
Australian Journal of Experimental Biology & Medical Science, 1957, Vol 35, Issue 3, p257
- ISSN
0004-945X
- Publication type
Academic Journal
- DOI
10.1038/icb.1957.28