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- Title
STUDIES ON THE HEPATO-ENCEPHALOMYELITIS VIRUS (HEV).
- Authors
Stanley, N. F.; Dorman, D. C.; Ponsford, Joan
- Abstract
Further properties of the hepato-encephalomyelitis virus are described. A description of the neurotropic variant (<em>N.</em>HEV) is given and the manner in which the change from a gastro-intestinal parasite (H.HEV) to a neurotropic one may be controlled and brought about by laboratory manipulation is also described. A study of the antibody content of aboriginal native sera revealed that complement-fixing antibodies were present in 18 p.c. of the sera tested. All sera reacting this way also reacted strongly with the Wassermann antigen. Monkeys infected with either variant developed a positive Wassermann reaction. HEV was shown to be highly resistant to heat and germicides. Filtration through gradocol membranes revealed a size of approximately 100-150 mμ. Mice infected with H.HEV were characterized by the production of copious faecal material of high fat content as well as by jaundice, oily hair effect, alopecia and incoordination. Both <em>N.</em>HEV and H.HEV produced pocks following primary inoculation of the chorio-allantois from infected mouse tissue. The pocks could not be demonstrated after four successive passages on the chorio-allantois. The properties of HEV are compared with those of other viruses, and it is thought to be distinct from any virus yet described. The possibilities of HEV being associated with infection in Australian aborigines are discussed.
- Publication
Australian Journal of Experimental Biology & Medical Science, 1954, Vol 32, Issue 4, p543
- ISSN
0004-945X
- Publication type
Academic Journal
- DOI
10.1038/icb.1954.56