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- Title
Neuroprotective Effect of Potassium Comenate Against Glutamate Toxicity on the Model of Cultured Rat Cerebellar Neurons.
- Authors
Shurygina, L.; Kravtsov, A.; Zlishcheva, E.; Nemchinova, E.; Bukin, D.
- Abstract
The study demonstrated neuroprotective action of novel chemical agent, potassium salt of comenic acid, against the glutamate-induced cytotoxicity on the model of cultured cerebral neurons. Potassium comenate (0.001-1.0 mM) significantly decreased the rate of glutamateinduced neuronal death. The highest viability of the cultured neurons during postglutamate time was observed when potassium comenate was applied in a concentration of 0.1 mM.
- Publication
Bulletin of Experimental Biology & Medicine, 2014, Vol 158, Issue 1, p49
- ISSN
0007-4888
- Publication type
Academic Journal
- DOI
10.1007/s10517-014-2689-4