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- Title
The 11β-Hydroxysteroid Dehydrogenase Type 1 (hsd11b1) Is Associated with Fasting Hyperglycemia and Obesity in Koreans.
- Authors
Yunhyi Ku; Bo Kyung Koo; Hyoung Doo Shin; Sunghoon Yu; Sung Hee Choi; Soo Lim; Min Kyong Moon; Jae Hyun Kim; Young Min Cho; Kyong Sop Park; Hak Chul Jang; Hong Kyu Lee
- Abstract
Glucocorticoid regulates many metabolic processes, such as hepatic gluconeogenesis, which makes it to influence on plasma glucose level. The 11β-hydroxysteroid dehydrogenase type1 (HSD11B1) convert inactive cortisone to active cortisol in several glucocorticoid target tissues including liver and adipose tissue and regulates glucose homeostasis. In animal model, it was reported that selective inhibition of HSD11B1 showed low plasma glucose level. In this study, we examined whether the HSD11B1 polymorphisms are associated with type 2 diabetes and its related phenotypes in Korean population. By direct DNA sequencing in twenty-four individuals, we identified common polymorphisms (frequency > 5%) in HSD11B1 gene, and performed an association study comprising 732 type 2 diabetes patients and 620 control subjects. Two common polymorphisms were identified (g.-19835G>A and g.27810C>T) in HSD11B1 gene. There was no association between variations of HSD11B1 gene and type 2 diabetes. However, g.-19835G polymorphism and g.27810C polymorphism were associated with fasting plasma glucose level with statistical significance (P=0.021 and 0.043, respectively). Furthermore, g.-19835G also showed the significant association with homeostasis model assessment - insulin resistance (P=0.035) and BMI (P=0.029) after adjusting for age, sex as a additive model. When we analyzed the data as a dominant model, g.-19835G was associated with waist circumference only in females (P=0.035) after adjusting for age. Polymorphisms in HSD11B1 showed significant association with fasting plasma glucose, insulin resistance and obesity, although they were not associated with susceptibility to type 2 diabetes.
- Publication
Diabetes, 2007, Vol 56, pA301
- ISSN
0012-1797
- Publication type
Academic Journal