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- Title
Circulating High Molecular Weight Adiponectin Levels Are Related to Obesity hut not to Insulin Sensitivity in Healthy and Glucose Tolerant Caucasians.
- Authors
Rahnema, Fariba; Pourbabak, Sam; Al-Sayed, Mohamad; Chang, Everett; Kwan, Connie; Wei Feng; Chiu, Ken C.
- Abstract
Adiponectin is a cytokine derived from adipose tissue and circulating in plasma mainly as low molecular weight hexamer and high molecular weight (HMW) multimer. It is a unique serum protein, has been studied in a variety of contexts and is proposed to have anti-diabetic, anti inflammatory and anti-atherogenic properties. Although the correlations of adiponectin with obesity and insulin sensitivity have been well publicized, much less is known about the HMW adiponection. We conducted a cross sectional study by enrolling 71 healthy and glucose tolerant Caucasians [27±6 years old, 55% females, body mass index (BMI) 24.27±3.93 kg/m²]. Insulin sensitivity was estimated using the homeostasis model assessment (%S) and Quantitative Insulin Sensitivity Check Index (QUICKI) from fasting samples. Total and HMW adiponectin were determined in fasting samples. The correlations of adiponectin with BMI and insulin sensitivity were investigated. HMW adiponectin was inversely correlated with BMI (beta coefficient=-0.3584, P=0.002) and positively correlated with both %S (beta coefficient=0.2839, P=0.02) and QUICKI (beta coefficient=0.2628, P=0.03). As BMI was a primary determinant for %S (beta coefficient=0.4652, P=0.00004) and QUICKI (beta coefficient=-0.42810, P=0.0002), we considered BMI as one of the co-variants in addition to age and gender. After adjustment for age, gender, and BMI, we found no correlation of HMW adiponection with either %S or QUICKI. Similarly, both total adiponectin and ratio of total:HMW adiponectin were inversely correlated with BMI (beta coefficient=-0.3841, P=0.0009 and beta coefficient=-0.2955, P=0.002, respectively). Again, neither total adiponectin nor ratio of total:HMW adiponectin was correlated with %S or QUICKI after adjustment for age, gender, and BMI. In summary, we observed an inversed correlation of total, HMW, ratio of HMW:total adiponectin with BMI in healthy and glucose tolerant Caucasians. However, the correlation of adiponectin with insulin sensitivity (%S and QUICKI) was most likely mediated through BMI and adiponectin had no independent impact on insulin sensitivity after adjustment for age, gender, and BMI.
- Publication
Diabetes, 2007, Vol 56, pA351
- ISSN
0012-1797
- Publication type
Academic Journal