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- Title
Voxel-Based Morphometry Detects Brain Volume Changes Due to Hypo- and Hyperglycemia in Youth with Type 1 Diabetes Mellitus (TIDM).
- Authors
Perantie, Dana C.; Wu, Jenny; Koller, Jonathan M.; Lim, Audrey; Warren, Stacie L.; Black, Kevin J.; Sadler, Michelle; White, Neil H.; Hershey, Tamara
- Abstract
Controversy persists about effects of T1DM on the developing brain. We have reported qualitative differences in cognitive measures associated with hypo- vs. hyperglycemia in T1DM. To quantify brain volume differences with T1DM, we acquired T1-weighted magnetic resonance images (MRI) in youth (7-17 years old) with T1DM (n=108) and sibling controls (n=51). T1DM subjects were categorized as having no vs. any prior severe hypoglycemia (SH). Hyperglycemia was estimated using median HbA1c weighted for duration of T1DM (wt-A1c). Whole brain voxel-based morphometry (SPM5) with multiple comparison correction was used to determine effects of SH and wt-A1c on gray and white matter. There were no significant differences between T1DM and HC. T1DM subjects with SH had significant reduction in gray matter in the left superior temporal region (p=.001; Fig. 1) whereas those with higher wt-A1c had significant reductions of gray matter in right cuneus and precuneus (p=.02) and white matter in right posterior parietal (p=.01; Fig. 2), and increased gray matter in right prefrontal cortex (p=.008). In summary, there are qualitatively different effects of SH and hyperglycemia on the brain in youth with T1DM of relatively short duration (mean 5.7 years). Future studies will investigate whether these differences relate to cognitive deficits and how age of exposure to glycemic extremes modulates these effects.
- Publication
Diabetes, 2007, Vol 56, pA476
- ISSN
0012-1797
- Publication type
Academic Journal