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- Title
Pilot Diffusion Tensor Imaging Study in Youth with Type 1 Diabetes Mellitus Reveals Change in White Matter Integrity Associated with Chronic Hyperglycemia.
- Authors
Wu, Jenny; Perantie, Dana C.; Sadler, Michelle; White, Neil H.; Hershey, Tamara
- Abstract
Type 1 diabetes mellitus (T1DM) has been hypothesized to affect white matter integrity in the developing brain, particularly in relation to chronic hyperglycemia. This pilot study is the first to explore the relationship between chronic hyperglycemia and white matter microsiructure in the developing brain with diffusion tensor imaging (DTI). Subjects with TIDM (n=22; 9-18 years old) and no history of severe hypoglycemia were studied. Exposure to hyperglycemia was estimated using lifetime median HbA1c weighted for the duration of T1DM (wt-A1c). Eight diffusion-weighted magnetic resonance images were acquired for each subject, and individual fractional anisotropy (FA) maps were calculated to assess white matter microstructure. Tract-Based Spatial Statistics (TBSS; Smith 2006) methods were used for image registration and analyses. Wt-A1c values were correlated with FA maps, controlling for age; multiple comparison corrections were applied (Randomise; Nichols 2002). A significant negative correlation was found between wt-A1c and FA values in the left superior occipital white matter, adjacent to the cuneus (p=0.02; 249 voxels; see Figure; mean FA values from significant cluster are shown). This finding suggests that increased hyperglycemia exposure is associated with decreased microstructrual integrity of white matter in T1DM youth. Whether white matter changes are also associated with hypoglycemia or with changes in cognitive performance in these patients will require further analyses.
- Publication
Diabetes, 2007, Vol 56, pA477
- ISSN
0012-1797
- Publication type
Academic Journal