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- Title
HsdBlu:LE Rat: An Alternative Model of Adiposity, Hyperglycemia, Glucose Intolerance and Insulin Resistance to the C57B1/6NHsd Mouse.
- Authors
Fredenburg, Natalie J.; Stevens, Karla A.; Mickelson, Barbara D.
- Abstract
Currently seven percent of the United States population is diabetic and the incidence continues to increase. Between 1999 and 2005, NIH funding for diabetes based research increased 222%. The most popular and well-characterized diet induced animal model of diabetes and obesity is the C57BL/6 mouse. The Long Evans rat is a similar model shown to also express characteristics of adiposity, hyperglycemia, glucose intolerance and insulin resistance. Fifty male C57B1/6NHsd mice and HsdBlu:LE rats were reserved at weaning and maintained on adjusted fat diet TD.95217 (40%kcal of fat, Harlan Teklad, Madison, WI) and Global Diet 2018S (5%kcal of fat, Harlan Teklad, Madison, WI) provided ad libitum. Group housed rats showed an average weight gain of 50 grams and C57B1/6 mice 5 grams weekly for the first six weeks of maintenance. The cohorts maintained on TD.95217 had increased mean body weights as early as one week of maintenance than cohorts fed Teklad Global Diet 2018S. The TD.95217 cohorts developed insulin resistance, fasting and fed hyperglycemia, glucose intolerance, and hyperleptinemia. In summary both diets produced models of obesity and prediabetes; however, the Long Evans rat offers the advantages of increased size and blood sampling volume.
- Publication
Diabetes, 2007, Vol 56, pA691
- ISSN
0012-1797
- Publication type
Academic Journal