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- Title
The Impact of Hyperglycemia on Morbidity 1-Year Following Kidney Transplant.
- Authors
Prieto, Luz M.; Puig, Alvaro; Meneghini, Luigi
- Abstract
Diabetes, which is often present either before or following organ transplantation, increases the risk of renal graft loss, cardiovascular disease, and death. We conducted a retrospective medical record review to assess the frequency and causes of hospital re-admission in the first year post-transplant in patients with and without pre-transplant diabetes undergoing kidney transplantation at Jackson Memorial Hospital/University of Miami between 2004 and 2006. A total of 512 patients underwent first kidney transplantation, either cadaveric or living donor. Most subjects were male (67%), 18-74 years old. Two hundred and four (39.8%) had pre-transplant diabetes (group 1). Of those without diabetes (group 2; n= 308) renal failure was mostly due to hypertension or chronic polycystic kidney disease. Of those in group 2, 18% developed post-transplant diabetes (defined as average blood glucose >126mg/dL during fasting lab work done during the first year post-transplant). The frequency of post-transplant diabetes in our study was comparable with previously published data. The frequency of re-admission during the first year was higher in group 1 (52.9%) compared to group 2 (23%) (p<0.001). Patients in group 2 who developed post-transplant diabetes had a higher frequency of re-admission compared to those in the same group that did not (29% vs. 21%, p=NS). The reasons for re-admission were similar between groups, the most common being infection (group 1=36% vs. group 2= 40.8%), acute rejection (group 1=38.8% vs. group 2=15.5%), and congestive heart failure (group 1= 15.7% vs. group 2= 15.5%). In conclusion, pre-transplant diabetes and possibly post-transplant diabetes are associated with a higher rate of post-transplant complications requiring readmission to the hospital. Further work in this area is required to evaluate the effect of strict glucose control on short and long-term post-transplant morbidity and mortality.
- Publication
Diabetes, 2007, Vol 56, pA717
- ISSN
0012-1797
- Publication type
Academic Journal