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- Title
EFFECTS OF PHYSICAL EXERCISE ON BONE REMODELING AND NEUROGENESIS IN MICE EXPOSED TO FLUORIDE.
- Authors
Rui-Yan Niu; Zi-Long Sun; Ji-Xiang Wang; Rui Li; Zhen-Zhen Guo; Jin-Ming Wang; Jian-Hai Zhang; Jun-Dong Wang
- Abstract
In order to study on the effects of physical exercise (PE) on bone remodeling and neurogenesis in developing mice treated with fluoride, mouse pups were exposed to 100 mg NaF/L through drinking water from postnatal days 21 to 70. Meanwhile, the mice also exercised at the speed of 5 m/min for 2 hr/day. The results showed that exposure to 100 mg NaF/L significantly enhanced the serum alkaline phosphatase activity and the ratio of the receptor activator of nuclear factor kappa B ligand and osteoprotegerin (RANKL: OPG), while the expression of osterix (OSX), runt-related transcription factor 2-I (RUNX2-1) in femur, and postsynaptic density-95 (PDS-95) in hippocampus were reduced. In addition, the daily PE reversed the changes in the indexes mentioned above. These findings suggest that physical exercise can weaken the impact of F on bone and nervous system by preventing the F-induced changes in the expression of bone and synaptic markers.
- Publication
Fluoride, 2019, Vol 52, Issue 1, p93
- ISSN
0015-4725
- Publication type
Academic Journal