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- Title
A Comparison of the antibacterial efficacy of two commercially available toothpaste formulations containing 0.3% Triclosan.
- Authors
Latimer, Joe; Munday, Jodie L.; Buzza, Kara M.; McBain, Andrew J.
- Abstract
Brief Background This investigation reports on the comparison of two commercially available toothpaste formulations containing 0.3% triclosan; Colgate Strong Teeth (ST) and Pepsodent GermiCheck Superior Power (PD). The antimicrobial effects of each formulation, particularly against Streptococcus mutans, an agent of dental caries, were determined by using a variety of in vitro methods. Materials and Methods Minimum inhibitory and bactericidal concentrations (MIC and MBC, respectively) to oral bacteria (S. mutans and Actinomyces viscosus) were determined using a broth microdilution method. Inhibitory effects against S. mutans were also measured using agar-based disc diffusion assays. A microbial viability assay using a redox dye examined the immediate antimicrobial effects of toothpastes on established cultures of S. mutans. Tests included a fluoride toothpaste as a control. Results Although MIC revealed no significant difference between the toothpastes in inhibitory potency, ST was significantly more inhibitory than PD in diffusion-based studies (p<0.001). In MBC and redox dye-based microbial viability assessments, ST and PD were equally effective. Both test formulations were significantly more effective than the control paste in all cases. Conclusion Taken together, the results of this multi-approach investigation do not consistently show significant differences between Colgate Strong Teeth and Pepsodent GermiCheck Superior Power for antimicrobial effects on oral bacteria including those associated with caries.
- Publication
JIDA: Journal of Indian Dental Association, 2014, Vol 8, Issue 2, p18
- ISSN
0019-4611
- Publication type
Academic Journal