We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Excess Insulin Binding to Insulin-Like Growth Factor Receptors: Proposed Mechanism for Acanthosis Nigricans.
- Authors
Cruz Jr., Ponciano D.; Hud Jr., Joseph A.
- Abstract
Clinical and epidemiologic evidence has shown acanthosis nigricans to be closely related to defective tissue utilization of insulin in a number of previously recognized (e.g., obesity, lipodystrophy, and leprechaunism) as well as recently characterized (e.g., type A and type B syndromes) disorders. This article reviews the relationship of acanthosis nigricans to these insulin-resistant states. It also focuses attention on the possibility that interaction between excessive amounts of circulating insulin with insulin-like growth factor receptors on keratinocytes and dermal fibroblasts leads to the development of acanthosis nigricans.
- Publication
Journal of Investigative Dermatology, 1992, Vol 98, Issue 6, p82S
- ISSN
0022-202X
- Publication type
Academic Journal
- DOI
10.1111/1523-1747.ep12462293