We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
On a Possible Protective Effect of HLA-A11 Against Skin Cancer and Keratotic Skin Lesions in Renal Transplant Recipients.
- Authors
Bavinck, Jan N. Bouwes; Kootte, Antoinette M. M.; Woude, Fokko J. Van Der; Vandenbroucke, Jan P.; Vermeer, Bert J.; Claas, Frans H. J.
- Abstract
Renal transplant recipients who have skin cancer potentially related to human papillomavirus were HLA typed with a special focus on HLA-A11, which in nonimmunosuppressed patients is negatively associated with the occurrence of virus-related carcinoma of the cervix. We found also a negative association between HLA-A11 and skin cancer; none of the 66 transplant recipients with skin cancer were positive for HLA-A11. As HLA-A11 seems to have a protective effect against skin cancer, we speculate that antigens induced by squamous cell carcinomas and possibly also by human papillomavirus may be efficiently presented through HLA-A11 to cytotoxic T cells. We also investigated a possible influence of other HLA alleles on the susceptibility of renal transplant recipients to skin cancer. The frequency of HLA-B27 was significantly higher in the transplant recipients with skin cancer, with a relative risk of 3.4 relative to healthy controls. No significant differences were found for other HLA class I or class II antigens.
- Publication
Journal of Investigative Dermatology, 1991, Vol 97, Issue 2, p269
- ISSN
0022-202X
- Publication type
Academic Journal
- DOI
10.1111/1523-1747.ep12480376