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- Title
Identifying potential candidate genes in an Irish bipolar disorder sample linked to 14q21-32.
- Authors
F., Cassidy; C., Zhao; J., Badger; C., Delaney; L., Mooney; S., Roche; P., McKeon; S. E., Dobrin
- Abstract
Bipolar affective disorder (BPAD) is a severe and debilitating psychiatric illness. Family, twin and adoption studies have established a substantial genetic component to the illness but the genes involved have yet to be fully elucidated. A 10cM genome-wide linkage scan (WGS) was performed in a collection of 60 Irish BPAD affected sib pairs to locate chromosomal regions that may harbour susceptibility genes. The most significant result was on chromosome 14 at 75cM (14q24). Since the region of the chromosome containing significant P values was substantial, we undertook a fine-mapping analysis to refine the linkage peak. 144 SNP markers (400kb resolution) were analysed in an extended sample of 88 ASPs. Linkage analysis resolved our original linkage peak into 4 separate peaks, two of which overlap with published linkage peaks for related psychiatric disorders, such as anxiety and alcoholism. The most significant NPL score of 2.71 was at 67.84Mb, remarkably close to the original WGS peak score at 68.2Mb. In an additional analysis, two SNPs were found to be associated with BPAD (rs24166076 at 46.97Mb and rs4902942 at 71.21Mb). This project has substantially refined the region of chromosome 14 predicted to contain a candidate susceptibility gene for BPAD.
- Publication
Ulster Medical Journal, 2008, Vol 77, Issue 1, p76
- ISSN
0041-6193
- Publication type
Academic Journal