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- Title
Different responses of cortical and juxtamedullary arterioles to norepinephrine and angiotensin II.
- Authors
Steinhausen, Michael; Ballantyne, David; Fretschner, Matthias; Hoffend, Johannes; Parekh, Niranjan; Dussel, Rudolf
- Abstract
Cortical (C) and juxtarnedullary (JM) glomerular blood flow were measured with intravitalmicroscopic techniques in the split hydronephrotic kidney of female Wistar rats under Inactin® anesthesia. Intravenous injection of small, equivalent pressor doses of norepinephrine (NE) and angiotensin II (Ang II) reduced the diameter of C afferent arterioles by -l6 ± 2.4% and -14 ± 1.9%, respectively, whereas that of JM afferent arterioles was reduced by only -3.8 ± 2.7% and -3.8 ± l.5% Blood flow under NE and Ang II was reduced in C glomeruli by -42 ± 4.9% and -37 ± 4.0%, respectively, but in JM glomeruli was reduced by -10 ± 6.2% and -8.6 ± 2.9% of control. Perfusion pressure reduction during NE or Ang II infusion to preinfusion values revealed autoregulatory behavior only in C glomeruli. In a second series of experiments cyclooxygenase inhibition by local administration of indomethacin (2.8 x 10-5 M) induced C and JM vasoconstriction, The effects of NE and Ang II during local application of indomethacin were variable but different responsiveness of C and JM vessels disappeared. We assume that the differences in NE and Ang II responsiveness between C and JM vessels under control conditions are caused by a high prostaglandin content or sensitivity, particularly of JM vessels in the hydronephrotic kidney.
- Publication
Kidney International Supplement, 1990, Issue 30, pS-55
- ISSN
0098-6577
- Publication type
Academic Journal
- DOI
10.1111/1523-1755.ep17660323