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- Title
Visceral Leishmaniasis in Latin America and therapy perspectives.
- Authors
Tovar A., Catalina; Yasnot A., María
- Abstract
In Latin America, visceral leishmaniasis is caused by Leishmania infantum. In this geographical area, main vectors associated with transmission are Lutzomyia longipalpis and Lutzomyia evansi, with dogs being incriminated as the main reservoir involved in transmission of the disease. This pathology primarily affects children between 0 - 5 years, a highly susceptible population where socio-economic, environmental and nutritional factors affects the pathological outcome and increase the likelihood of vector-human contact. According to the World Health Organization (WHO) recommended treatment for Visceral Leishmaniasis is liposomal amphotericin B, a drug with a limited and variable availability between countries depending on market prices, which leaves pentavalent antimonial as the most widely used treatment despite the associated toxic effects. In the Americas, evidence on the efficacy of single-dose (monotherapy) and combination therapies as options for treating these parasites is required.
- Publication
Revista MVZ Córdoba, 2017, Vol 22, p6075
- ISSN
0122-0268
- Publication type
Academic Journal
- DOI
10.21897/rmvz.1077