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- Title
Carbohydrate metabolism in Corynebacterium glutamicum and applications for the metabolic engineering of l-lysine production strains.
- Authors
Blombach, Bastian; Seibold, Gerd
- Abstract
Carbohydrates exclusively serve as feedstock for industrial amino acid production with Corynebacterium glutamicum. Due to the industrial interest, knowledge about the pathways for carbohydrate metabolization in C. glutamicum steadily increases, enabling the rational design of optimized strains and production processes. In this review, we provide an overview of the metabolic pathways for utilization of hexoses (glucose, fructose), disaccharides (sucrose, maltose), pentoses ( d-ribose, l-arabinose, d-xylose), gluconate, and β-glucosides present in C. glutamicum. Recent approaches of metabolic engineering of l-lysine production strains based on the known pathways are described and evaluated with respect to l-lysine yields.
- Publication
Applied Microbiology & Biotechnology, 2010, Vol 86, Issue 5, p1313
- ISSN
0175-7598
- Publication type
Academic Journal
- DOI
10.1007/s00253-010-2537-z