We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Marcadores de estrés metabólico, inflamatorio y oxidativo en la variación del óxido nítrico de los individuos de hemodiálisis.
- Authors
Epifânio, Andreza P. Santos; Balbino, Karka P.; Jorge, Mônica de P.; Ribeiro, Sônia. M. R.; Moreira, Ana Vládia B.; Oliveira, Jerusa M.; Oliveira, Leandro L.; Hermsdorff, Helen Hermana M.; Santos Epifânio, Andreza De Paula; Balbino, Karla Pereira; Jorge, Monica De Paula; Ribeiro, Sonia M R; Moreira, Ana Vládia Bandeira; Oliveira, Jerusa Maria; Oliveira, Leandro Licursi; Hermsdorff, Helen Hermana Miranda
- Abstract
<bold>Introduction: </bold>Oxidative stress markers such as nitric oxide (NO) have been investigated in hemodialysis (HD).<bold>Objective: </bold>Evaluate the association of NO variation with adiposity indicators, metabolic, inflammatory and oxidative stress markers in individuals to HD.<bold>Methods: </bold>Cross-sectional study with 85 subjects on HD treatment (≥ 18 years). The clinical-nutritional status was evaluated through subjective global assessment modified (SGAm), anthropometric measurements and body composition. Dietary intake was evaluated using a food frequency questionnaire. Metabolic markers were obtained from medical records. Inflammatory markers (IL-6 and IL-10) and oxidative stress, (TACs), (SOD), (GST), (MDA) and NO were determined using standardized protocols.<bold>Results: </bold>Those individuals with a high concentration of NO (> 4.32 μmol/L) had lower values for SGAm score (p = 0.012) and higher iron values (p = 0.050), Fe saturation (p = 0.037) and triacylglycerol (p = 0.003). The same subjects still had lower consumption of copper (p = 0.026), manganese (p = 0.035), vitamin E (p = 0.050), ω3 (p = 0.021) and ω6 (p = 0.020). In a multiple regression model, concentrations of ferritin, triacylglycerol, IL6 and SOD contributed to a 54.8% increase in NO concentrations, whereas triacylglycerol and SOD concentrations were independent factors for NO variation (p < 0.001). CONCLUSIONS: The clinical and nutritional status as well as intake of nutrients with antioxidant properties (Cu, Zn, Mn, vitamin C and ω3) appears to modulate the variation of NO in this population.
- Publication
Nutrición Hospitalaria, 2018, Vol 35, Issue 1, p176
- ISSN
0212-1611
- Publication type
Academic Journal
- DOI
10.20960/nh.1319