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- Title
The Effects of Acute and Chronic Hyperglycemia on Serum Paraoxonase Activity.
- Authors
Ormen, Murat; Bozkaya, Giray; Tuncel, Pinar; Onman, Turgut; Sisman, Ali Riza; Karaca, Baysal
- Abstract
Objectives: Paraoxonase (PON1) is a high density lipoprotein bound serum esterase that is synthesized by the liver which has ability to metabolize lipid peroxides hence playing an important role in protection against atherosclerosis. Our aim was to evaluate the effect of acute and chronic hyperglycemia on PON1 activity in order to clarify the effect of glucose homeostasis. Besides, the relation of hemoglobin A1c with triglyceride, total cholesterol, low density lipoprotein-cholesterol, high density lipoprotein-cholesterol and PON1/high density lipoprotein-cholesterol ratios which play role in the development of atherosclerosis was also evaluated. Design and methods: Chronic effects were investigated in Type 2 diabetes patients (n=290) divided into three groups according to their HbA1c levels (group 1: <7%, group 2: 7-8.9%, group 3: ≥9%). Oral glucose tolerance test applied 192 subjects were evaluated for acute effects. Results: No significant difference was observed in PON1 activities between the groups (p>0.05) and there was no correlation between PON1 activity, PON1/HDL-C ratio and HbA1c. PON1 activities decreased during OGTT (p<0.05) and were insignificantly lower in the subjects with normal glucose tolerance. Conclusion: Our findings indicate that although there is a tendency of lowered PON1 activity in long term hyperglycemia, the difference was not significant between different HbA1c levels. However, acute hyperglycemia leads to significant decreases in PON1 activity. Conflict of interest: Authors did not declare any conflict of interest.
- Publication
Turkish Journal of Biochemistry / Turk Biyokimya Dergisi, 2011, Vol 36, Issue 2, p160
- ISSN
0250-4685
- Publication type
Academic Journal