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- Title
P201 - PROTECTIVE EFFECTS OF N-ACETYLCYSTEINE AND MISOPROSTOL FROM CONTRAST AGENT AND DICLOFENAC IN RENAL TOXIC EFFECTS.
- Authors
Mehmet Bü$yü$kş$erbetci; Mü$mtaz Dadalı$; Ahmet Metin Hasç$iç$ek; Elmas Ö$ğ$ü$ş$; Aytü$n Ş$adan Kı$lı$nç$; Muzaffer Eroğ$lu
- Abstract
Aim: In this study, rats with unilateral ureteral obstruction to what extent with protective effect of N-Acetylcysteine at renal toxic radiopaque iv contrast agent is given and protective effect of misoprostol (Prostaglandin E1 analog) at renal toxic diclofenac agent is given is scheduled. Material and methods: In this study, 22 Wistar albino female rats were randomized into 5 groups. 2 rats were spared for control group. Right ureter were sutured with 4/0 vicryl sutures. Rats were grouped into control, contrast agent, contrast agent + NAC, diclofenac and diclofenac + misoprostol. Radiopaque contrast agent was given iv. in 3rd day and others was given orally for 1 week. Rats were sacrified after 1 week biochemical oxidative stress markers malondialdehit,protein carbonyl groups and SH levels were studied. Result: The group with obstruction that contrast agent and NAC was given had higher rates of antioxidant SH level (p<0,05) and lower rates of oxidative end product carbonyl groups (p<0,05) compared to only contrast agent given group. No difference was seen in MDA levels statistically (p>0,05). No difference was seen between diclofenac group and diclofenac and misoprostol group statistically (p>0,05). Conclusion: N-Acetylcysteine is protective against contrast agent when given before and after administration in obstructed kidneys. No protective effect was seen in misoprostol against diclofenac in obstructed kidney.
- Publication
Turkish Journal of Biochemistry / Turk Biyokimya Dergisi, 2012, Vol 37, Issue S1, p342
- ISSN
0250-4685
- Publication type
Academic Journal