We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synthetic N-Aralkylated-N-(2,4-dimethylphenyl)benzenesulfonamides: As Potent Anti-Bacterial Agents.
- Authors
Siddiqui, Sabahat Zahra; Sarwar, Afzaal; Abbasi, Muhammad Athar; Aziz-ur-Rehman; Hussain, Mazhar; Ahmad, Irshad; Ali Shah, Syed Adnan
- Abstract
The current research effort embodies the assessment of anti-bacterial potential of some N-substituted sulfonamides. The synthetic methodology was triggered by reaction of 2,4- dimethylaniline (1) with benzenesulfonyl chloride (2) at pH 9-10 in aqueous sodium carbonate (10 %) to generate N-(2,4-dimethylphenyl)benzenesulfonamide (3) which was further treated with different aralkylated halides (4a-e) in polar aprotic medium; N, N-dimethylformamide (DMF) and lithium hydride (LiH) which acts as base under stirring at room temperature for 3 hours to afford Naralkylated- N-(2,4-dimethylphenyl)benzenesulfonamides (5a-e). The proposed structures of sulfonamides were explicated via contemporary spectral methods e.g. IR, 1H-NMR, 13C -NMR and EIMS. Moreover, they were analyzed against different Gram (-) and (+) bacterial strains to unravel their inhibitory potential. The amalgamation of sulfonamide moiety with different aralkyl halides resulted in good anti-bacterial activity compared to standard; Ciprofloxacin. N-2-bromobenzyl-N- (2,4-dimethylphenyl)benzenesulfonamide (5d) and N-2-phenylpropyl-N-(2,4- dimethylphenyl)benzenesulfonamide (5b) contributed significantly which may be attributed to the successful and fruitful N-insertion of 2-bromobenzyl and 2-phenylpropyl moieties on parent sulfonamide.
- Publication
Journal of the Chemical Society of Pakistan, 2016, Vol 38, Issue 6, p1151
- ISSN
0253-5106
- Publication type
Academic Journal