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- Title
Isolation and Enzyme Inhibitory Studies of Steroids and Alkaloidal Steroid Saponins from Solanum surattense Burm.f.
- Authors
Mukhtar, Mahreen; Nazir, Mamona; Riaz, Naheed; Tousif, Muhammad Imran; Khan, Saima; Ashraf, Muhammad; Ali, Muhammad Shaiq; Ahmad, Ishtiaq; Jabbar, Abdul; Saleem, Muhammad
- Abstract
Two new alkaloidal steroid glycosides; solanoid A and B (1 and 2), along with two known alkaloidal steroid glycosides; solamargine (3) and khasianine (4) a known steroidal saponin; dioscin (5), a benzoylated steroid, carpesterol (6) methyl caffeate (7), ferulic acid (8) and oleic acid (9) were isolated from the methanolic extract of Solanum surattense. The new compounds were identified through 1D and 2D NMR techniques, and high resolution mass spectrometric analysis, while the known compounds were elucidated due to 1D NMR, mass spectrometry and in comparison with the literature values of their spectroscopic data. Compounds 1-6 were evaluated for anti-α- glucosidase, anti-urease and antioxidant activity, where only compound 6 inhibited the activity of α- glucosidase with IC50 value of 42.26 μM.
- Publication
Journal of the Chemical Society of Pakistan, 2018, Vol 40, Issue 3, p556
- ISSN
0253-5106
- Publication type
Academic Journal