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- Title
Polymorphisms of TNF-α gene and HSP70-2 gene in patients with acute pancreatitis.
- Authors
HU Jiaping; ZHUANG Jianxin; LI Yong; YU Yonghuan; HU Qinghong; LAI Yinying; WU Antao
- Abstract
Objective To investigate the association of tumor necrosis factor (TNF)-α, heat shock protein (HSP)70-2 gene polymorphisms and susceptibility of acute pancreatitis(AP). Methods Using case-control method,The gene polymorphism of TNF-a and HSP70-2 was detected by PCR-RLFP in 72 patients with AP and 71 healthy controls. Results There were no significant differences in proportion of TNF-a genotype and alleles between AP and control groups (P > 0.05). There were no significant differences in TNF-α genotype and alleles between severe acute pancreatitis (SAP) and light acute pancreatitis (MAP) of AP group (P > 0.05). There were no significant differences in white blood cell count, C-reactive protein (CRP), amylase, three acyl glycerin and glucose between TNF-α and HSP70-2 gene of AA type and GA + GG type patients (P >0.05). The HSP70-2 genotype GA+GG proportion was significantly higher in AP group than that of control group (69.4% vs 49.3%). The ratio of patients with G allele was significantly higher in AP group than that of control group (46.5% vs 31.7%). The ratio of patients with GA + GG type AP was significantly higher in SAP patients than that of MAP patients of AP group (81.0% vs 53.3%). There was no significant difference in G allele between SAP and MAP patients (P>0.05). Conclusion TNF-α polymorphisms is not associated with acute pancreatitis. There is an association between HSP70-2 polymorphisms and acute pancreatitis. Carrying the G allele increases the possibility of a severe acute pancreatitis, which is one of the genetic susceptibility factors of severe acute pancreatitis.
- Publication
Tianjin Medical Journal, 2015, Vol 43, Issue 1, p57
- ISSN
0253-9896
- Publication type
Academic Journal
- DOI
10.3969/j.issn.0253-9896.2015.01.015