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- Title
Unusual adverse events following peripheral blood stem cell (PBSC) mobilisation using granulocyte colony stimulating factor (G-CSF) in healthy donors.
- Authors
Hilbe, W.; Nussbaumer, W.; Bonatti, H.; Thaler, J.; Niederwieser, D.; Nachbaur, D.
- Abstract
Here, we describe two cases of severe pyogenic infection in healthy donors diagnosed immediately following stem cell mobilisation with G-CSF. In the first donor a painful perianal abscess and in the second one an apical abscess required surgical incision. The reported serious adverse events in the literature are reviewed and the potential pathophysiological role of G-CSF or GM-CSF in augmenting inflammatory processes is discussed. In the light of a rapidly increasing number of related and unrelated peripheral blood stem cell donations the need for more comprehensive donor work-up and follow-up for peripheral blood stem cell donors has to be considered.
- Publication
Bone Marrow Transplantation, 2000, Vol 26, Issue 7, p811
- ISSN
0268-3369
- Publication type
Academic Journal
- DOI
10.1038/sj.bmt.1702581