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- Title
Neuroprotective Agents: Is Effective on Toxicity in Glial Cells?
- Authors
Ozlem Yilmaz; Dilek Taskiran; Gonul Peker
- Abstract
??1. Glial cells are the most abundant cell population in the central nervous system. The aim of this study was to examine the effects of melatonin, 7-nitroindazole, and riluzole on glutamate toxicity in primary glial cell culture.2. Glutamate toxicity was induced by addition of 100??M glutamate to the cultures, and then 100??M melatonin, 500??M 7-nitroindazole, and 10?(M riluzole were administered in different groups. Lactate Dehydrogenase activity and nitrite levels were determined at the 1st, 6th, and 24th?h.3. Melatonin, 7-nitroindazole, and riluzole decrease Lactate Dehydrogenase activity at the 1st, 6th, and 24th?h (at all hours,p<0.05). Nitrite levels were decreased by melatonin and riluzole at the 1st, 6th, and 24th?h.4. In this study, we observed that melatonin, 7-nitroindazole, and riluzole are effective as protective agents on glutamate toxicity in mixed glial cells.
- Publication
Cellular & Molecular Neurobiology, 2007, Vol 27, Issue 2, p171
- ISSN
0272-4340
- Publication type
Academic Journal