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- Title
Oxidative stress and non-enzymatic glycation in IgA nephropathy.
- Authors
Vas, T.; Wagner, Z.; Jenei, V.; Varga, Z.; Kovács, T.; Wittmann, I.; Schinzel, R.; Balla, G.; Balla, J.; Heidland, A.; Nagy, J.
- Abstract
Aim: Approximately 20-50% of IgA nephropathy patients develop end-stage renal disease. We have previously found enhanced oxidative stress and decreased antioxidant capacity in red blood cells of IgA nephropathy patients. In this study we assess oxidative stress, non-enzymatic glycation, oxidative resistance of low-density lipoprotein and its α-tocopherol content in these patients. Patients and methods: Non-enzymatic glycation and oxidative stress were assessed in 88 IgA nephropathy patients by measuring advanced glycation end products, Nϵ-carboxy-methyl-lysine, thiobarbituric acid reactive substances, oxidative resistance of low-density lipoprotein and its α-tocopherol content. Results: Advanced glycation end products (2659 ± 958 a.u.) and Nϵ-carboxymethyl-lysine (563 ± 215 ng/ml) were significantly higher in IgA nephropathy patients with decreased renal function compared to those with normal renal function (p < 0.002) or controls (p < 0.001). Thiobarbituric acid-reactive substances in plasma and associated with low-density lipoprotein were significantly elevated and oxidative resistance of low-density lipoprotein was significantly reduced in all groups of IgA nephropathy patients. There was no significant difference in circulating fluorescent advanced glycation end products, Nϵ-carboxymethyl-lysine, thiobarbituric acid-reactive substances levels, oxidative resistance of low-density lipoprotein and its α-tocopherol content between patients with normal vs. impaired glucose metabolism. Low α-tocopherol content of low-density lipoprotein was accompanied with decreased oxidative resistance, depletion in polyunsaturated fatty acids, elevated saturated fatty acids and thiobarbituric acid-reactive substances within low-density lipoprotein suggesting enhanced lipid peroxidation. Conclusions: Decreased oxidative resistance of low-density lipoprotein and enhanced oxidative stress are common features in IgA nephropathy, while increased non-enzymatic glycation occurs as renal function declines.
- Publication
Clinical Nephrology, 2005, Vol 64, Issue 5, p343
- ISSN
0301-0430
- Publication type
Academic Journal
- DOI
10.5414/CNP64343