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- Title
CORRELATION BETWEEN SERUM LEVEL OF HEART TYPE FATTY ACID BINDING PROTEIN (H-FABP) AND N-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE (NT-PROBNP) ON ACUTE CORONARY SYNDROME PATIENT.
- Authors
Nurwahyudi; Aminuddin, M.
- Abstract
Heart-type fatty acid-binding protein (H-FABP) is an early marker of cardiac necrosis and shows good correlation with infarct size. N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP) is released as a response of wall stress and myocyte stretch. This study aims to analyze correlation between serum level of H-FABP and NT-proBNP on acute coronary syndrome (ACS) patients (n=34) in Emergency Department and Coronary Care Unit of Dr. Soetomo General Hospital, Surabaya. H-FABP and NT-proBNP concentration were measured using RELIA TM Immunoassay Diagnostic Instrument (SSJ-2) Kit with ELISA method on 1 and 6 hours after admission. Mean of H-FABP concentration at 1 and 6 hours after admission consecutively were 35.202882 + 45.0928572 ng/mL H(1) and 35.907147 + 44.6597609 ng/mL(H6). Mean of NT-proBNP concentration at 1 and 6 hours after admission consecutively were 2040.3062 + 4169.89471 pg/mL (N1) and 2683.3376 + 4190.6605 pg/mL (N6). No significant differences between H1 and N1; H6 and N6. H1, N1, H6, N6 were significantly higher on myocardial infarct than unstable/stable angina patients. There were positive correlation of H1 and N1 (p=0.014, r=0.419), H6 and N6 (p=0.001; r=0.527). There was a positive correlation between peak H1 and N1 (p=0.000; r=0.570) and between peak H6 and N6 (p=0.027; r=0.378). There was strong positive correlation between levels of H-FABP and NT-proBNP on ACS patients.
- Publication
Folia Medica Indonesiana, 2014, Vol 50, Issue 2, p73
- ISSN
0303-7932
- Publication type
Academic Journal