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- Title
FURTHER ELUCIDATION OF NEUROPROTECTIVE PROPERTIES OF ASTROCYTOMA (ASTROCYTES-LIKE) CELLS.
- Authors
Wong, Yin Yin Wendy; Jaiswal, Ashvin R.; Bhushan, Alok; Leung, Solomon W.; Lai, James C. K.
- Abstract
Astrocytes protect neurons against various assaults although the underlying pathophysiological and molecular mechanisms are poorly understood. Therefore, we have continued to develop cell models in vitro to further investigate the putative neuroprotective properties of astrocyte-like astrocytoma cells. We hypothesized that different stress factors can elicit and/or enhance the neuroprotective effects of astrocytes through the activation of astrocytic survival signaling and alteration of astroglial function. Employing cell models involving astrocytes-like U87 astrocytoma and neurons-like SK-N-SH cells, results of our previous and ongoing studies suggest that U87 cells protect SK-N-SH cells against cytotoxicity due to oxidative stress. Other ongoing studies target the putative neuroprotective effect(s) of U87 cells due to alterations of cell signaling and/or other astroglial function(s). Thus, our results may have implications for the pathophysiology of neuroprotection.
- Publication
Journal of the Idaho Academy of Science, 2010, Vol 46, Issue 1, p52
- ISSN
0536-3012
- Publication type
Academic Journal