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- Title
Comparative characterization of cinnamon, cinnamaldehyde and kaempferol for phytochemical, antioxidant and pharmacological properties using acetaminophen-induced oxidative stress mouse model.
- Authors
Hussain, Zulfia; Khan, Junaid Ali; Arshad, Muhammad Imran; Muhammad, Faqir; Abbas3, Rao Zahid; Moreno, Miguel; Moreno Murillo, Barbara
- Abstract
This study was aimed to explore the comparative efficacy of cinnamon bark extract, cinnamaldehyde and kaempferol against acetaminophen (APAP)-induced oxidative stress. Cinnamon bark extract, cinnamaldehyde and kaempferol were utilized for in-vivo analysis. From the results of invitro screening tests, cinnamon ethanolic extract was selected for in-vivo study in mouse model. For this, Balb/c albino mice were treated with cinnamon ethanolic extract (200 mg/kg), cinnamaldehyde (10 mg/kg) and kaempferol (10 mg/kg) orally for 14 days followed by single intraperitoneal administration of APAP during 8 hours. Blood and organ samples were collected for biochemical and histopathological analysis. The results showed that cinnamon bark ethanolic extract, cinnamaldehyde and kaempferol ameliorated APAP-induced oxidative stress and organ toxicity in mice. In conclusion, cinnamaldehyde and kaempferol possess comparable antioxidant potential even at 20-times less dose as compared to cinnamon bark ethanolic extract suggesting therapeutic potential in oxidative stress-related disorders.
- Publication
Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 2021, Vol 20, Issue 4, p339
- ISSN
0717-7917
- Publication type
Academic Journal
- DOI
10.37360/blacpma.21.20.4.25