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- Title
Aortic Arch Stenosis Caused by Minimally Invasive Surgery in Mouse Heart Failure Model.
- Authors
Xin Zhou; Huangtao Sun; Zhihong Qiu; Xudong Ye; Shan Wan; Aimin Xie
- Abstract
Heart failure refers to damage to the structure and function of the heart caused by various reasons, impairing the contraction and diastolic function of the ventricle, and causing abnormal hemodynamics. The purpose of this article is to study the application effect of aortic arch stenosis caused by minimally invasive surgery in the model of heart failure in mice, establish a model of heart failure in mice by minimally invasive surgery, and randomly divide the mice into sham operation group and constriction group. The narrowing group underwent minimally invasive surgery for ligation of the aortic arch through the neck incision, and the sham operation group was the same as the narrowing group except not ligating. The results of the study showed that the mortality of aortic arch narrowing during operation and within 24 hours after surgery was 11% (8/75), and the mortality rate at 1 week after surgery was 7.5% (5/66); the mortality rate during and after surgery was 20% (15/75), no one died in the 60 sham operation group. Compared with the sham-operated group, the LVFS% values of mice with moderate and severe aortic constriction decreased to varying degrees, especially in severely constricted mice, the decrease was most obvious (43.8+1.08 vs. 21.6+1.18, p <0.01). Therefore, aortic arch stenosis caused by minimally invasive surgery can successfully prepare a mouse model of heart failure.
- Publication
Acta Microscopica, 2020, Vol 29, Issue 5, p2578
- ISSN
0798-4545
- Publication type
Academic Journal