We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Soybean Isoflavones on the Morphology and Ultrastructure of Hippocampus in Alzheimer's disease Model Rats Induced by Aβ25~35.
- Authors
Hui Zhou; Wei Chen; Huiqing Feng
- Abstract
In recent years, the number of AD patients has shown a gradual upward trend globally. Soy isoflavones have the effects of enhancing immunity and weak estrogen-like, antioxidant and cut cancer cell growth. Therefore, the purpose of this article is to study the effect of soybean isoflavones on the morphology and ultrastructure of hippocampus in Alzheimer's disease (AD) model rats induced by Aβ25-35. The method in this paper is to use experimental comparison method to randomly divide 60 experimental rats into model control group, sham operation group, Aβ+ low-dose soybean isoflavone group (26.3mg⋅kg-1⋅d-1), Aβ+ High-dose soybean isoflavones (52.6mg⋅kg-1⋅d-1) and Aβ+estrogen group were injected with Aβ25-35 bilateral hippocampus. By adjusting different doses of soybean isoflavones, bioactive molecules were extracted for HE staining. Subsequently, the effect of soybean isoflavones on the morphology and ultrastructure of hippocampus was observed by electron microscope. Through analysis and determination, it can be found that in the model group, the number of neurons in the hippocampal CA1-CA4 area and dentate gyrus of the rat is significantly reduced by 24%, and there are many cytoplasmic staining of nerve cells. In the three groups of the experimental group, the number of neurons increased compared with the model group and the sham operation group, and the number of cytoplasmic stained neurons was relatively small. Compared with the model control group, the neurons were less polluted by 21%, but some nerves were present Phenomenon such as cell membrane shrinkage, the nuclear membrane as a whole is relatively complete, the model group has fewer neurons in the hippocampal CA1 area, and the cell body shrinks. According to the data comparison, the corresponding conclusion is that the abnormal neurons in the hippocampal CA1 area ofthe soybean isoflavone-related treatment group are significantly reduced compared with the model group, which can effectively improve the loss of hippocampal neurons in AD rats caused by Aβ25-35 and ensure normal tissue morphology and structure.
- Publication
Acta Microscopica, 2020, Vol 29, Issue 6, p3099
- ISSN
0798-4545
- Publication type
Academic Journal