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- Title
The Genetics and Neurochemistry of Schizophrenia and Addiction: Enhanced Options for Treatment Using Nicotinic Acid (Vitamin B<sub>3</sub>).
- Authors
Maclean, Malcolm
- Abstract
The role ofoxidative stress has been reviewed in a variety of psychiatric disorders, particu-larly schizophrenia and alcoholism (index cases), which are associated with deficiency of protective enzymes: superoxide dismutase and catalase, respectively. The reported effectiveness of nicotinic acid in the treatment of schizophrenia and alcoholism appears to be due to enhanced levels of nicotinamide adenine dinucleotide (NAD), thereby opposing the deleterious effects of genetically determined neu-ronal oxidative stress, arguably an important final common pathway in schizophrenia and alcohol-ism. The potential for nicotinic acid supplementation to remit schizotypy (schizoid traits) in family members containing an index case has been proposed and such a case is described. This report hints at the potential role of nicotinic acid in remitting an array of psychiatric disorders linked genetically and biochemically to schizophrenia.
- Publication
Journal of Orthomolecular Medicine, 2013, Vol 28, Issue 2, p55
- ISSN
0834-4825
- Publication type
Academic Journal