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- Title
A new prognostic score for the survival of patients with esophageal squamous cell carcinoma.
- Authors
Nakamura, Masaki; Iwahashi, Makoto; Nakamori, Mikihito; Ojima, Toshiyasu; Katsuda, Masahiro; Iida, Takeshi; Hayata, Keiji; Kato, Tomoya; Yamaue, Hiroki
- Abstract
Purpose: Recent studies have shown that the modified Glasgow Prognostic Score (mGPS), which is an inflammation-based prognostic score, is useful as a prognostic index for some cancer cases. The purpose of this study was to create a prognostic scoring system for patients with esophageal squamous cell carcinoma (ESCC) that was more independent and sensitive than the mGPS. Methods: One hundred sixty-eight patients who had undergone esophagectomy for ESCC were included in the study. The new mGPS (NmGPS) was calculated based on the following cutoff values: CRP >0.75 mg/dL indicated NmGPS 1 or 2, depending on the absence or presence of hypoalbuminemia (<3.5 g/dL); and CRP ≤0.75 mg/dL indicated NmGPS 0. We also performed an analysis based on cutoff values of 0.5 and 0.25 mg/dL for CRP. Results: Only the NmGPS with a cutoff CRP value of 0.5 mg/dL was able to divide into three independent patient groups in the survival curves. In the multivariate analyses, a NmGPS (CRP cutoff; 0.5 mg/dL) of 2 was a more significant independent prognostic factor (HR 4.437, 95 % CI 2.000-9.844, p = 0.0002) than a mGPS of 2 (HR 2.726, 95 % CI 1.021-7.112, p = 0.0449). Conclusions: The new prognostic score NmGPS (CRP cutoff; 0.5 mg/dL) was more independent and sensitive than the mGPS for patients with ESCC.
- Publication
Surgery Today, 2014, Vol 44, Issue 5, p875
- ISSN
0941-1291
- Publication type
Academic Journal
- DOI
10.1007/s00595-013-0628-z