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- Title
Iron and iron-related parameters in oncology.
- Authors
Könemann, S.; Bölling, T.; Matzkies, R.; Willich, N.; Kisters, K.; Micke, O.
- Abstract
Iron is a central element in the metabolism of normal and malignant cells. Besides the oxygen binding, iron plays an important role in many systems like oxygen metabolism, electron transfer via cytochromes and as metal cofactor for enzymes. The iron resorption, the cellular transport, the markers of iron metabolism and storage and their clinical relevance is reviewed. The metabolism of iron is influenced by cellular mechanisms mediated by different cell types like T lymphocytes as well as macrophages and different cytokines like interferon (IFN) γ, tumor necrosis factor (TNF) α and interleukin-1 (IL-1) 1. Pathophysiology of iron in chronic infections and tumors, anemia of chronic diseases (ACD) and substitution therapy as well as the impact on the use of erythropoietin are discussed.
- Publication
Trace Elements & Electrolytes, 2005, Vol 22, Issue 2, p142
- ISSN
0946-2104
- Publication type
Academic Journal