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- Title
The effect of hyperglycemia on zinc, copper and chromium status in STZ-induced diabetic rats.
- Authors
Krejpcio, Z.; Wójciak, R. W.; Król, E.
- Abstract
Background/Aims: Diabetes mellitus is a disorder in which blood glucose levels are abnormally high because the body does not produce enough insulin or insulin is unable to make glucose accessible to cells. Poor glucose control brings about progressive complications in various body functions, and affects mineral status. The aim of this study was to evaluate the concentration of Zn Cu and Cr in organs and tissues of STZ-induced diabetic in rats. Methods: Male Wistar rats (n = 8) were made diabetic Type 1 by STZ-injection while the untreated rats (n = 8) served as the control. The concentrations of Zn, Cr and Cr in organs were measured after microwave wet mineralization by the flame and flameless AAS method. Results: Hyperglycemia induced by STZ-injection significantly increased Zn contents in kidney (by 52 %), spleen (by 14%) and testes (by 9%), and elevated Cu levels (by 57%) in kidney and liver (by 300%), but did not affect tissular Cr contents in rats. Conclusions: Prolonged poor glucose control disturbs Zn and Cu metabolism in rat.
- Publication
Trace Elements & Electrolytes, 2011, Vol 28, Issue 3, p156
- ISSN
0946-2104
- Publication type
Academic Journal
- DOI
10.5414/TEP28156