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- Title
Isoflavones influence the extent of plasma cholesterol reduction by soy protein.
- Authors
Thorp, A.; Morris, A.; Buckley, J.; Mori, T.; Hodgson, J.; Meyer, B.; Howe, P.
- Abstract
Background -- Regular consumption of soy protein (SP) has been shown to significantly reduce plasma total cholesterol (TC) and triglycerides (TG). However, the potential contribution of isoflavones (ISO) associated with the SP to its lipid lowering effects remains unclear. The relative requirements for SP and ISO are critical to the development of more palatable soy products that can deliver this health benefit. Objectives -- To enhance the palatability of soy by combining it with dairy so that daily consumption of soy is more readily achievable by consumers. To assess the relative impact on plasma lipids of regular consumption of soy and soy/dairy formulations. Design -- A double blinded randomised crossover intervention trial incorporating three 6-week long dietary phases in 35 volunteers with elevated TC (>5.5mM). The trial was designed to compare cardiovascular benefits of eating soy foods (S) or soy/dairy combination foods (S/D) with that of dairy foods (D). Intended daily nutrient intakes from foods on each diet were 24g of SP + 80mg of ISO on the S diet, 12g of both SP and dairy protein (DP) + 80mg of ISO on the S/D diet and 24g of DP on the D diet. Outcomes -- ISO intakes on the S and S/D diets were less than anticipated (57 and 70mg/day respectively). TC was 4.4% lower (P <0.05) while subjects consumed S compared to D but was unaltered by the S/D diet, despite a higher daily ISO intake. The S diet also tended to improve LDL, HDL and TG levels. Regression analysis revealed that the extent of TC reduction was dependent on an individual's intake of ISO (P <0.05). Conclusions -- Combining DP with SP has the potential to enhance consumer acceptability of soy products. However, soy protein intakes exceeding 12g/day appear necessary to significantly reduce TC. The magnitude of reduction is dependent on the concomitant ISO intake.
- Publication
Asia Pacific Journal of Clinical Nutrition, 2005, Vol 14, pS75
- ISSN
0964-7058
- Publication type
Academic Journal