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- Title
190: Computerized Tomography Measurement of Visceral Adiposity Predicts Plasma Adiponectin Levels and Presence of Metastatic Disease in Patients with Clear Cell Renal Cell Carcinoma.
- Authors
Kapoor, Anil; Chatterjee, Suman; Kleinman, Nir; Khambati, Aziz; Pinthus, Jehonathan H.
- Abstract
Introduction: Obesity is a risk factor for renal cell carcinoma (RCC). We have recently shown that plasma levels of adiponectin, a hormone secreted solely by adipocytes, inversely correlates to adverse prognostic factors in clear cell RCC, but not with body mass index (BMI). The purpose of this study was to develop a quantitative method of measuring visceral obesity and to correlate it to adiponectin levels and disease characteristics. Methods: Blood samples were collected pre-operatively from a cohort of 25 patients (11 with metastatic disease) confirmed to have clear cell RCC (stage T1-T3). Visceral and peripheral fat content was measured using pre-operative CT. Three representative slices were analyzed, the top of L2 vertebral body, umbilicus and the anterior superior iliac spine. Tissue at fat density was digitally extracted from each image, separated into subcutaneous and visceral components and then the number of pixels was summed across three slices to create a surrogate score of visceral and peripheral fat. This score was correlated to plasma adiponectin levels, tumour size, grade, presence of metastasis and BMI. Results: Using linear regression analysis, plasma adiponectin correlated inversely with the size of the tumor (P<0.01) but not with BMI. BMI correlated strongly with CT total fat and peripheral fat measurements (P<0.01) but not visceral fat measurement. Similarly, visceral obesity correlated inversely with plasma adiponectin levels (P=0.04) and with the presence of metastasis (P=0.03 by logistic regression) but not with other prognostic factors. Conclusions: Using a novel and easily reproducible method to quantify adiposity we have shown that visceral obesity correlates with aggressive disease and lower levels of plasma adiponectin in RCC.
- Publication
Indian Journal of Urology, 2008, Vol 24, pS116
- ISSN
0970-1591
- Publication type
Academic Journal