We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Development of New Shellac Based pH Responsive Polymer for Biomedical Applications.
- Authors
Barik, Arundhati; Parhi, P.; Dey, R. K.
- Abstract
Shellac (Sh) was chemically modified to produce a new pH responsive hydrogel material. The material was characterized using various advanced instrumentation techniques such as Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM),Differential Scanning Calorimeter (DSC) and Thermo-Gravimetric Analyzer (TGA). The kinetics ofthermal decomposition was evaluated using Coats-Redfern (CR) and Kissinger-Akahira-Sonuse (KAS) mathematical models resulting in computation of Arrhenius equationsfor both shellac(k = (3.4 x 1021) e-159.9/RT sec-1) and chemically modified shellac (k = (122) e-18.44/RT sec-1). Chemically modified shellac shows 1417% swelling in buffer solution.The controlled release of a model drug 5-amino salicylic acid (5-asa) from the polymeric matrix follows Fick's diffusion equation indicating future potential application in various pharmaceutical field of research.
- Publication
Trends in Biomaterials & Artificial Organs, 2015, Vol 29, Issue 3, p237
- ISSN
0971-1198
- Publication type
Academic Journal