We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
HEPATOPROTECTIVE ACTIVITY OF STEMS OF MIMOSA HAMATA (WILLD.) AGAINST CARBON TETRACHLORIDE INDUCED TOXICITY.
- Authors
N. I., Khan; B. C., Hatapakki
- Abstract
The aqueous and ethanolic extract of stems of Mimosa hamata (Willd.) at the dose of 200mg/kg & 400 mg/kg body weight per oral was studied for the hepatoprotective effect using Carbon tetrachloride induced liver damage in Wistar albino rats. Ethanolic extract showed significant (p<0.05) hepatoprotective effect by lowering the serum levels of various biochemical parameters such as serum glutamic oxaloacetate transaminase (SGOT), serum glutamic pyruvates transaminase (SGPT), alkaline phospatase (ALP), Bilirubin indirect test (BIT). These biochemical observations were in turn confirmed by histopathological examinations of liver sections and are comparable with the standard hepatoprotective drug Silymarin (100mg/kg body weight i.p.) which served as a positive control. The overall experimental results suggests that the biologically active phytoconstituents such as flavonoids, tannins and carbohydrates present in the ethanolic extract of plant Mimosa hamata, may be responsible for the significant hepatoprotective activity and the results justify the use of Mimosa hamata as a hepatoprotective agent.
- Publication
Advances in Pharmacology & Toxicology, 2019, Vol 20, Issue 1, p1
- ISSN
0973-2381
- Publication type
Academic Journal