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- Title
ACRYLONITRILE - INDUCED MITOCHONDRIAL DYSFUNCTION: NEUROPROTECTIVE ROLE OF ALA VIA ENHANCEMENT OF OXIDATIVE STRESS IN RATS.
- Authors
Kumar, Sunil; Kumar, Praveen
- Abstract
Neurotoxicity produced by chemicals such as nitriles has always been associated with the process of oxidative stress. In this process, the mechanism involved for the generation of free radicals plays significant role. Acrylonitrile, an extensively used nitrile in the production of plastic and related products, is responsible for producing neurotoxicity. The free radical induced neurotoxicity may be effectively prevented by Alpha lipoic acid (ALA) mainly by virtue of its antioxidant nature. The present work involves the investigation of effects of acrylonitrile (50mg/kg body weight) and ALA (100mg/kg body weight) on hippocampal mitochondrial enzyme activities such as and MnSOD (manganese Superoxide dismutase), GPx (glutathione peroxidase), GST (glutathione-stransferase) and non-enzymic GSH (reduced glutathione) respectively. The damage on mitochondrial membrane was also studied by measuring MDA (malondialdehyde) level. It was observed that acrylonitrile administration significantly down regulated the activities of the enzymes whereas ALA restored the levels of the enzymes. The results indicate that ALA effectively protects the hippocampal mitochondrial damage provoked by acrylonitrile and thus emerges as a potential substance that can be extensively explored in related areas of research.
- Publication
Advances in Pharmacology & Toxicology, 2014, Vol 15, Issue 1, p31
- ISSN
0973-2381
- Publication type
Academic Journal