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- Title
Standardization and xanthine oxidase inhibitory potential of Solanum virginianum.
- Authors
Devi, B. Vaishnavi; Priya, V. Vishnu; Gayathri, R.
- Abstract
Introduction: Gout is a systemic disorder which usually affects the joints of the body system with an increased incidence rate in the elderly people. The cause for gout is accumulation of uric acid in the body. Elimination of the uric acid crystals is done by inhibition of xanthine oxidase (XO) which is responsible for the conversion of xanthine to uric acid. Here, we have preferred the plant extract Solanum virginianum for XO inhibition which is said to have more expectorant properties with least side effects. Materials and Methods: The study included preparation of the plant extract and XO inhibitory activity was measured spectrophotometrically based on the procedure reported by Nguyen et al. and was compared with the standard drug allopurinol. Results: The inhibitory potential of the plant extract against XO activity is increasing with increasing concentration with its maximum of 60.8% obtained at 100 μg/ml. Conclusion: S. virginianum has a significant effect against the XO activity and, hence, can be preferred for the future uses in the prognosis of gout as it has less side effects when compared to the corticosteroids.
- Publication
Drug Invention Today, 2019, Vol 11, Issue 9, p2220
- ISSN
0975-7619
- Publication type
Academic Journal