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- Title
Burn wound healing activity of Aloe vera powder in gel dosage form.
- Authors
Budiman, Arif
- Abstract
Aim: The aim of this study was to evaluate the activity of burn healing of Aloe vera (AV) powder in gel dosage form. Materials and Methods: The powder of AV was formulated into the base of gel containing variations in the concentration of carbomer and sterilized by gamma radiation. The gel preparations of AV were evaluated including organoleptic, pH, viscosity, and sterilization of gel. A burn healing evaluation was performed by making a wound with a hot plate on the skin of rabbits. Then, 600 mg of AV powder gel was applied to the burn wound. After that, the presence of erythema and width contraction of the burns was observed for 15 days after gel administration. Results: The result showed that the formulation containing 2.5% of carbomer and 20% of AV powder has the best physical stability. The gel preparations also did not show a significant difference in organoleptic, pH, and viscosity measurement after sterilization. The AV powder gel can increase the rate of healing process with the high percentage of burn wound contraction (60% after 7-day storage). Conclusion: It can be concluded that the gel of AV powder can increase the wound healing process of burns as well as safe as to be used as a topical dosage form.
- Publication
Drug Invention Today, 2020, Vol 13, Issue 1, p27
- ISSN
0975-7619
- Publication type
Academic Journal