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- Title
Synthesis of new compounds derived from 5-chloroindole and the study of their biological activity.
- Authors
Alkuwaity, Eman Abdul Wahab; Ghafil, Rajaa A. A.
- Abstract
Background: Indole is one of many sides heterocyclic nuclei compounds, specific as a pharmacophore in a large number of natural and synthetic biologically active molecules, indole and its derivatives are formed in interesting plants, in which indole derivatives exhibit different biological and pharmacological properties. Methodology: This paper contains some prepared heterocyclic compounds derived from 5-chloroindole, by the reaction between Meldrum's acid, 5-chloroindole, p-hydroxybenzaldehyde, and catalyst L-proline in acetonitrile to produce indole derivative (V), which ethanolyzed to give ester derivative (V1), then compound (V1) reacted with hydrazine hydrate to give hydrazide derivative compound (V2), hydrazide derivative reacted with p-hydroxy benzaldehyde in absolute ethanol to give Schiff base derivative(V3), Schiff base derivative used to prepare some new heterocyclic compounds by multistep reactions with different solvents, and materials to prepare four, five, and seven ring membered. The prepared compounds were characterized by Fourier transform infrared, ¹H-NMR, and 13C-NMR. All the prepared compounds were studied for antibacterial activity. Results: Most of the reactions were done with long periods, this is maybe due to the structure of starting material Meldrum's acid which contains indole ring, the study of antimicrobial activity for all the prepared compounds. Conclusion: Synthesis of Meldrum's acid derivatives for antibiotic drug containing indole, study the biological activity against the types of bacteria.
- Publication
Drug Invention Today, 2020, Vol 14, Issue 1, p79
- ISSN
0975-7619
- Publication type
Academic Journal