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- Title
Synthesis, characterization, and antibacterial, evaluation of new naproxen derivatives.
- Authors
Nsaif, Lubna H.; Al-Bayti, Redha I.; Kadhem, Sahar Ab.
- Abstract
In this work, naproxen derivatives were synthesized by the reaction of naproxen with H2SO4 using methanol to give ester (1). Compound (1) was synthesized by reaction of naproxen with hydrazine hydrate give 2-(6-methoxynaphthalen- 2-yl)propanehydrazide (2), compound (2) treatment with acetylacetone, ethyl acetoacetate, α-cyanoethylacetate, phenyl isothiocyanate, 4-nitro phenyl isothiocyanate, 4-chlorophenyl isothiocyanate, malic anhydride, succinic anhydride, and phthalic anhydride gave compounds (2a-i). Compound (2) reaction with 4-phenylphenacylbromide gives N'-(1-([1,1'-biphenyl]-4-yl)-2-bromoethylidene)-2-(6-methoxynaphthalen-2-yl)propanehydrazide (3), compound (3) reaction with hydrazide and phenyl hydrazide gives 6-([1,1'-biphenyl]-4-yl)-3-(1-(6-methoxynaphthalene-2-yl)ethyl)-N-phenyl or 1,2,4-triazin-4(5H)-amine (3a-b), and compound (4) reaction naproxen with thionyl chloride gives 2-(6-methoxynaphthalen- 2-yl)propanoyl chloride. Compound (4a-c) reaction compound (4) with secondary amine (piperidine, dicyclohexylamine, and diphenylamine) gives 2-(6-methoxynaphthalen-2-yl)-1-(alkyl-1-yl) propan-1-one-(4a-c). All naproxen derivatives have been characterized by 1H-nuclear magnetic resonance, infrared, and mass spectroscopy.
- Publication
Drug Invention Today, 2020, Vol 13, Issue 2, p252
- ISSN
0975-7619
- Publication type
Academic Journal