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- Title
Possible antidepressant potential of a cognitive enhancer Polygonum minus based on its major chemical constituents in leaf part.
- Authors
Bashir, Muhammad Irfan; Kaz Abdul Aziz, Nur Hidayah; Mohamed Noor, Dzul Azri
- Abstract
The current review is related to the potential of Polygonum minus leaf part against depression. Depression is worldwide largest problem which can cause the imbalance of neurotransmitters of brain, around 322 million people are living with this disorder according to latest survey of the World Health Organization. There is a need to find more options for the treatment of depression to cure it and to overcome or reduce the side effects of already existing treatment options. The phytomedicine can play an important role to discover the new targets against any disease. P. minus leaf has many beneficial constituents. Antidepressant potential of its major constituents has been explored in this up to date review, all data regarding this purpose have been collected from Web of Science, Google Scholar, Scopus, and PubMed. Our observations show that the leaf part of P. minus has large potential to become an antidepressant option in future, due to the presence of flavonoids specifically which are involved in memory-enhancing activity and increasing the level of neurotransmitters in brain according to their reported effects. Based on the observation of the current review, an experimental screening on antidepressant activity of P. minus leaf part is strongly recommended.
- Publication
Drug Invention Today, 2020, Vol 13, Issue 4, p549
- ISSN
0975-7619
- Publication type
Academic Journal