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- Title
Hepatoprotective activity of Bridelia retusa leaves against paracetamol-induced liver damage in Swiss albino mice.
- Authors
V. B., Ghawate; Shrivastava, Purnima; R. S., Bhambar
- Abstract
The present study is aimed to evaluating the hepatoprotective effect of Bridelia retusa leaves extracts by paracetamol-induced liver damage in swiss albino mice. The degree of protection was measured by using biochemical parameters such as serum glutamate oxalate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), bilirubin. Treatment with Bridelia retusa leaves extracts showed significant reduction in level of SGOT, SGPT, ALP and total bilirubin almost comparable to the Silymarin. The hepatoprotection confirmed by histopathological examination of the liver tissue. From the result it can be concluded that Bridelia retusa leaves possesses hepatoprotective effect against paracetamol-induced liver damage in mice.
- Publication
Drug Invention Today, 2017, Vol 9, Issue 1, p9
- ISSN
0975-7619
- Publication type
Academic Journal