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- Title
Prevalence and Predictors of Adverse Drug Effects with Second Line Anti-TB drugs Under Programmatic Management of Drug Resistant Tuberculosis (PMDT) Services in Amritsar District.
- Authors
Nagpal, Manisha; Kaur, Harpreet; Devgun, Priyanka; Chawla, Naresh
- Abstract
Introduction: The key to successful elimination of tuberculosis (TB) is treatment of cases with optimum chemotherapy. Irrational anti-TB drug use over time has led to drug resistant TB (MDR-TB/XDR-TB). The treatment of MDR-TB with second line drugs is long, complex and costly with considerable rates of adverse effects. The present study was conducted to understand the prevalence and predictors of these adverse effects in order to detect them early and be prepared to take proper steps when they occur. Materials and method: This cross-sectional study was conducted on all MDR-TB patients who were registered and being treated under PMDT services in Amritsar district from 1st April 2014 to 31st March 2015. All the possible adverse effects with their predictors were evaluated by enquiring about the related symptoms. Data management and analysis was done by using Microsoft excel and SPSS. Results: Out of 87 MDR-TB patients, 57 (65.5%) were males and 30 (34.4%) were females. More than half of the cases i.e. 66.6% among males and 76.7% among females were in the age group of 15-45 years. Male preponderance, with male to female ratio of approximately 2:1 was seen. Adverse effects were present in 92% cases. most common side effects observed were nausea and vomiting in 90.8% followed by Giddiness, over sleepiness, poor concentration, Arthralgia, yellow eyes or skin/abdominal discomfort, dark coloured urine, Skin rashes/pruritus, Blurring of vision, Psychiatric problems/suicidal tendencies, Oliguria/anuria/puffiness of face/pedal edema and others. Conclusion: On statistical analysis, it was observed that socio-economic status (p=0.02) and presence of addictions (p=0.00) significantly affected the occurrence of adverse effects. Other factors like age, sex, marital status, education, occupation and family type did not affect the occurrence of adverse effects.
- Publication
Indian Journal of Public Health Research & Development, 2018, Vol 9, Issue 1, p175
- ISSN
0976-0245
- Publication type
Academic Journal
- DOI
10.5958/0976-5506.2018.00032.3