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- Title
Role of Vitamin C as Antioxidant in Psoriasis Patients Treated with NB-UVB Phototherapy.
- Authors
Al-Katib, Sami R.; AL-Wakeel, Hadi A.; AL-Rawaf, Riyam F.
- Abstract
Background: Psoriasis is a chronic inflammatory skin disease that has been associated with abnormal plasma lipid metabolism and oxidative stress. Objective: To assess the anti-oxidative effect of vitamin C supplementation in psoriasis patients treated by NB-UVB phototherapy and its correlation with the disease severity. Method: A single blind randomized clinical trial included 74 patients with clinically diagnosed psoriasis, conducted at AL-Sadr Medical city and department of Laser research in AL-Najaf City during a period one year. The patients were assigned randomly in to two groups be treated with NB-UVB only or NB-UVB+V.C supplementation of (500mg) twice daily for 12 week and followed up to assess their responses. Result: Vitamin C and GSH were significantly increased while serum level of MDA significantly reduced, (p<0.05) in NB-UVB+V.C compared to NB-UVB only group. A significant decrease in GSH and increase in MDA (p<0.05). A statistically significant correlation (positive) was found between V.C and GSH and negative correlation was found between V.C and MDA levels after treatment(P<0.05) in NB-UVB+V.C group. PASI score was insignificantly correlated with V.C, GSH and MDA, (P>0.05). Conclusion: Vitamin C supplementation has a significant role as a safe anti-oxidant in psoriatic patients treated by NB-UVB phototherapy.
- Publication
Indian Journal of Public Health Research & Development, 2018, Vol 9, Issue 10, p375
- ISSN
0976-0245
- Publication type
Academic Journal
- DOI
10.5958/0976-5506.2018.01372.4